Sir Integra Hellsing and Seras Victoria from the Hellsing manga (yes, Integra is a gurrrrrl - - surprise!).  Integra was always the most fascinating character in that manga, for me at least.  And in this predicament, she can't smoke those foul little cigars of hers.

And I just noticed the design similarities between Integra and Balalaika in Black Lagoon, both physically and as characters.  Coincidence or influence?